Natural products have long been a vital source of novel lead compounds in drug discovery. Many drugs currently used as therapeutic agents have been derived from natural sources, with plants playing a particularly significant role. However, in recent decades, pharmaceutical companies have shown limited interest in natural product-based drug discovery, largely due to the inherent complexity of working with these substances. Recently, technological advancements have helped overcome many of these challenges, leading to a renewed scientific interest in exploring natural sources for drug development.........

Keywords: Drug discovery (DD), Bioactivity - guided (BG), Extraction, Isolation, Plant based natural products (PBNP), Ethno pharmacological (EP).